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EFFECT OF DMT
Pharmacology
Dimethyltryptamine is primarily a serotonin (5-HT) receptor agonist. Like many other chemicals in its class, DMT’s psychedelic actions can mostly be attributed to its effects on the 5-HT2A receptor. It does affect many other receptor types (including dopamine and sigma receptors), but the consequences of these interactions are not well understood.[2]
In a study that administered low, medium, or high doses to 12 volunteers, the psychedelic threshold for DMT was found to be 0.2 mg/kg. At this level, most biological effects were detectably altered. Adrenocorticotropin hormone, beta-endorphin, prolactin, growth hormone (GH), and cortisol were all elevated. Pupil diameter, heart rate, and blood pressure all peaked within 2 minutes of administration, as did subjective experiences.
A later trial found that the body does not build a tolerance to DMT, meaning there’s no need to take more to repeat the same effects, unlike other psychedelics such as LSD and psilocybin.[3], [4]
Toxicity
The exact toxic profile of DMT is unknown, but studies in rodents suggest that a lethal dose in humans would be extremely high—more than 20 times the typical dose given during an ayahuasca ceremony.
When experienced users were asked to rate its safety, 55% said DMT is “very safe” and 38% said “quite safe”.[5] The main risks they reported were a “bad trip” (51%), which is a considerably higher risk compared to other classic psychedelics.
Interactions with other drugs
DMT significantly affects the serotonin system and should not be taken simultaneously with any of the following substances:
- SSRI’s (any selective serotonin reuptake inhibitor, like Prozac)
- Antihypertensives (high blood pressure medicine)
- Appetite suppressants (diet pills)
- Medication for asthma, bronchitis, or other breathing problems; antihistamines; medicines for colds, sinus problems, hay fever, or allergies (any drug containing dextromethorphan/ DXM or with DM, DX or Tuss in its name)
- CNS (central nervous system) depressants (Xanax, Ativan, etc)
- Vasodilators
- Antipsychotics
- Barbiturates
- Alcohol
Illegal or recreational drugs that are dangerous to combine with DMT include:
- Cocaine
- Amphetamines (meth-, dex-, amphetamine), ephedrine, MDMA (Ecstasy), MDA, MDEA, PMA
- Opiates (heroin, morphine, codeine, and especially opium)
- Dextromethorphan (DXM)
- Nutmeg
Illegal or recreational drugs that can be dangerous to combine with DMT include:
- Mescaline (any phenethylamine)
- Barbiturates
- Alcohol
- Kratom
- Kava
- 5-MEO-DMT
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